Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease Myopathy

Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease Myopathy

This study investigates ferroptosis in the context of peripheral artery disease (PAD), a vascular disease characterized by atherosclerosis of the lower extremities. Muscle atrophy and increased oxidative stress are hallmarks of PAD and correlate with worse clinical outcomes. Given ferroptosis’ assoc...

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Bibliographic Details
Main Authors: Trevor Wilkinson, Emma Fletcher, Andrew Ring, Cassandra Bradley, Evlampia Papoutsi, Dimitrios Miserlis, Robert S. Smith, William T. Bohannon, Iraklis I. Pipinos, Panagiotis Koutakis
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biology
Subjects:
ferroptosis
peripheral artery disease
iron metabolism
oxidative stress
lipid peroxidation
autophagy
Online Access:https://www.mdpi.com/2079-7737/14/5/537
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https://www.mdpi.com/2079-7737/14/5/537

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