2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer

2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer

Several studies have suggested a potential antitumor effect of 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione (DMDD). To further understand the mechanism of action of this compound, we investigated its effect on the phosphatidylinositol‐3‐kinase (PI3K)/serine–threonine kinase (Akt)/mammalian targe...

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Bibliographic Details
Main Authors: Linqian Chen, Meifeng Chen, Yan Xie, Yuyan Zhang, Shutian Mo, Yongfei He, Tianyi Liang, Yuan Liao, Renbin Huang, Guodong Huang, Chuangye Han, Thi Thai Hoa Pham
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:FEBS Open Bio
Subjects:
autophagy
breast cancer
2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione
PI3K/Akt/mTOR signaling pathway
ROS
Online Access:https://doi.org/10.1002/2211-5463.13940
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https://doi.org/10.1002/2211-5463.13940

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