Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors

Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors

Abstract Obtaining single-cell spatial information remains a challenge in spatial transcriptomics. Here we develop SEU-TCA, a method that leverages transfer component analysis to improve single-cell spatial mapping accuracy. Application to multiple single-cell and spatial transcriptomic datasets sho...

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Main Authors: Jingjing He, Yi Yang, Rui Jiang, Yanying Zheng, Xianfa Yang, Xu Jiang, Xin Xue, Zhongzhou Yang, Naihe Jing, Hailong Cao, Zhuojuan Luo, Ke Wei, Peng Xie, Chengqi Lin
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Biology
Subjects:
Single-cell RNA sequencing
Spatial transcriptomic
Cardiac progenitors
Regulatory factors
Online Access:https://doi.org/10.1186/s13059-025-03633-3
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https://doi.org/10.1186/s13059-025-03633-3

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