MIDAA: deep archetypal analysis for interpretable multi-omic data integration based on biological principles

Abstract High-throughput multi-omic molecular profiling allows the probing of biological systems at unprecedented resolution. However, integrating and interpreting high-dimensional, sparse, and noisy multimodal datasets remains challenging. Deriving new biological insights with current methods is di...

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Bibliographic Details
Main Authors: Salvatore Milite, Giulio Caravagna, Andrea Sottoriva
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03530-9
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