Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa

Potential biomarker and composite efficacy readout for human clinical trials of schistosomiasis vaccine in Africa

Abstract Schistosomiasis is a chronic disease that inflicts high morbidity and significant mortality with an estimated 90% of cases occurring in sub-Saharan Africa. Development of a vaccine against schistosomiasis is a major global health goal. The SchistoShield (Sm-p80 + GLA-SE) vaccine has consist...

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Main Authors: Desalegn W. Kifle, Aravindan Kalyanasundaram, Adebayo J. Molehin, Mumtaz Y. Balkhi, Aryandra Arya, Weidong Zhang, Gul Ahmad, Workineh Torben, David Carey, James F. Papin, Lisa A. Jackson, Sean A. Gray, Darrick Carter, Afzal A. Siddiqui
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Schistosomiasis
SchistoShield
Efficacy readout
Correlates of protection
Clinical trial
Baboons
Online Access:https://doi.org/10.1038/s41598-025-05730-6
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https://doi.org/10.1038/s41598-025-05730-6

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