Development of novel multi-protein chimeric immunogens that protect against infection with the Lyme disease agent, Borreliella burgdorferi

ABSTRACT Lyme disease is the most common tick-borne disease in North America. A vaccine for use in humans is not available. Here, we detail the development of two chimeric vaccine antigens, BAF and Chv2M. BAF elicits Abs that target proteins and protein variants produced by Borreliella species in ti...

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Bibliographic Details
Main Authors: Nathaniel S. O’Bier, Andrew C. Camire, Dhara T. Patel, John S. Billingsley, Kelly R. Hodges, Richard T. Marconi
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
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Online Access:https://journals.asm.org/doi/10.1128/mbio.02159-24
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