Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.

The "mechanistic target of rapamycin" (mTOR) is a central controller of growth, proliferation and/or motility of various cell-types ranging from adipocytes to immune cells, thereby linking metabolism and immunity. mTOR signaling is overactivated in obesity, promoting inflammation and insul...

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Main Authors: Kassem Makki, Solenne Taront, Olivier Molendi-Coste, Emmanuel Bouchaert, Bernadette Neve, Elodie Eury, Stéphane Lobbens, Myriam Labalette, Hélène Duez, Bart Staels, David Dombrowicz, Philippe Froguel, Isabelle Wolowczuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092684&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0092684&type=printable

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