Charting γ-secretase substrates by explainable AI

Charting γ-secretase substrates by explainable AI

Abstract Proteases recognize substrates by decoding sequence information—an essential cellular process elusive when recognition motifs are absent. Here, we unravel this problem for γ-secretase, an intramembrane-cleaving protease associated with Alzheimer’s disease and cancer, by developing Comparati...

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Main Authors: Stephan Breimann, Frits Kamp, Gabriele Basset, Claudia Abou-Ajram, Gökhan Güner, Kanta Yanagida, Masayasu Okochi, Stephan A. Müller, Stefan F. Lichtenthaler, Dieter Langosch, Dmitrij Frishman, Harald Steiner
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60638-z
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https://doi.org/10.1038/s41467-025-60638-z

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