DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming

DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming

Abstract Low back pain (LBP), primarily driven by intervertebral disc degeneration (IVDD), has become a core challenge in public health. DDX1, an RNA-binding protein, plays key roles in RNA metabolism but its function in IVDD remains unclear. We identify DDX1 as a substrate of methyltransferase EZH2...

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Main Authors: Dingchao Zhu, Huaizhen Liang, Bide Tong, Zhi Du, Gaocai Li, Weifeng Zhang, Di Wu, Xingyu Zhou, Jie Lei, Xiaoguang Zhang, Liang Ma, Bingjin Wang, Xiaobo Feng, Kun Wang, Lei Tan, Yu Song, Cao Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61486-7
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https://doi.org/10.1038/s41467-025-61486-7

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