Exploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomas

Exploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomas

Abstract Broad-spectrum multi-target tyrosine kinase inhibitors (mTKIs) are clinically approved for the treatment of soft tissue sarcomas (STS). However, acquired resistance inevitably arises in the majority of STS patients. There is therefore an urgent need to identify new strategies to overcome re...

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Main Authors: Mark L. Elms, Andrew D. Jenks, Avirup Chowdhury, Lukas Krasny, Madhumeeta Chadha, Kaan Low, Peter T. Harrison, William G. Kerrison, Robin L. Jones, Paul H. Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08652-1
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https://doi.org/10.1038/s42003-025-08652-1

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