A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases

A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases

Abstract Background Melanoma brain metastases (MBM) have a unique molecular profile compared to extracranial metastases (ECM). Description of the biological features and clinical outcomes of MBM will facilitate the design of rational therapies. Methods We examined the mutational landscape and gene e...

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Main Authors: Lucy Boyce Kennedy, Amanda E. D. Van Swearingen, Marissa R. Lee, Layne W. Rogers, Alexander B. Sibley, Jeff Sheng, Dadong Zhang, Xiaodi Qin, Eric S. Lipp, Swaminathan Kumar, Aron Joon, Pixu Shi, Michael A. Davies, Kouros Owzar, Carey K. Anders, April K.S. Salama
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Acta Neuropathologica Communications
Subjects:
Melanoma
Brain metastases
Immune microenvironment
Macrophages
Autophagy
Online Access:https://doi.org/10.1186/s40478-025-02035-7
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https://doi.org/10.1186/s40478-025-02035-7

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