Influence of preoperative anti TNF alpha antibody therapy on postoperative recurrence of Crohn’s disease

Influence of preoperative anti TNF alpha antibody therapy on postoperative recurrence of Crohn’s disease

Abstract Anti-TNFα antibodies are effective in controlling intestinal inflammation caused by Crohn’s disease. However, many patients undergo surgery due to diminished efficacy of the antibodies during maintenance therapy. Currently, the decision between intensification of TNFα therapy and surgery is...

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Main Authors: Yuki Sekido, Takayuki Ogino, Takashi Takeda, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi, Tsunekazu Mizushima
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Crohn’s disease
Anti-TNF alpha
Preoperative treatment
Postoperative recurrence
Loss of response
Online Access:https://doi.org/10.1038/s41598-025-89834-z
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https://doi.org/10.1038/s41598-025-89834-z

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