Efficient mRNA delivery to resting T cells to reverse HIV latency

Efficient mRNA delivery to resting T cells to reverse HIV latency

Abstract A major hurdle to curing HIV is the persistence of integrated proviruses in resting CD4+ T cells that remain in a transcriptionally silent, latent state. One strategy to eradicate latent HIV is to activate viral transcription, followed by elimination of infected cells through virus-mediated...

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Main Authors: Paula M. Cevaal, Stanislav Kan, Bridget M. Fisher, Michael A. Moso, Abigail Tan, Haiyin Liu, Abdalla Ali, Kiho Tanaka, Rory A. Shepherd, Youry Kim, Jesslyn Ong, Denzil L. Furtado, Marvin Holz, Damian F. J. Purcell, Joshua M. L. Casan, Thomas Payne, Wei Zhao, Mohamed Fareh, James H. McMahon, Steven G. Deeks, Rebecca Hoh, Sushama Telwatte, Colin W. Pouton, Angus P. R. Johnston, Frank Caruso, Jori Symons, Sharon R. Lewin, Michael Roche
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60001-2
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https://doi.org/10.1038/s41467-025-60001-2

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