The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma

Abstract Background Immunotherapy has emerged as an effective treatment for lung adenocarcinoma (LUAD) in recent years. However, the ability of cancer cells to suppress antitumor immune responses through multiple mechanisms has become one of the major challenges for therapy. PYCR1 can reinforce the...

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Bibliographic Details
Main Authors: Kui Liu, Xiaoyan Yang, Xuemei Tang, Bo Tang
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Online Access:https://doi.org/10.1007/s00262-025-04144-7
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