Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives

Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives

Abstract Natural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical development as an anticancer agent. Herein, twenty novel tanshinone I-pyridinium salt derivatives and a pyridinium salt precursor were designed and synthesized, and their ant...

Full description

Saved in:
Bibliographic Details
Main Authors: Huimin Zhao, Yuyang Wang, Zining Liu, Lin Lin, Jiasi Xiang, Zihao Zhu, Xiongli Yang, Yongsheng Fang, Lingmei Kong, Yan Li
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:Natural Products and Bioprospecting
Subjects:
Tanshinone I
Pyridinium salts
Structural modification
Antitumor activity
Structure–activity relationship
Online Access:https://doi.org/10.1007/s13659-025-00534-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1007/s13659-025-00534-7

Similar Items