Charged Thienobenzo-1,2,3-Triazoles as Especially Potent Non-Selective Cholinesterase Inhibitors: Design, Anti-Inflammatory Activity, and Computational Study

Charged Thienobenzo-1,2,3-Triazoles as Especially Potent Non-Selective Cholinesterase Inhibitors: Design, Anti-Inflammatory Activity, and Computational Study

<b>Background/Objectives</b>: This research reports the synthesis and evaluation of novel charged thienobenzo-triazoles as non-selective cholinesterase inhibitors (AChEs and BChEs), their anti-inflammatory properties, and a computational study. <b>Methods</b>: Fifteen derivat...

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Main Authors: Antonija Jelčić, Anamarija Raspudić, Danijela Barić, Ana Ratković, Ivana Šagud, Paula Pongrac, Dora Štefok, Martina Bosnar, Sunčica Roca, Zlata Lasić, Ilijana Odak, Irena Škorić
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
thienobenzo-1,2,3-triazoles
cholinesterase
BChE inhibitors
anti-inflammatory activity
molecular docking
ADME-Tox prediction
Online Access:https://www.mdpi.com/1424-8247/18/7/1032
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https://www.mdpi.com/1424-8247/18/7/1032

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