(<i>E</i>)-2-Benzylidenecyclanones: Part XX—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions

(<i>E</i>)-2-Benzylidenecyclanones: Part XX—Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions

In vitro relative cytotoxicity (IC<sub>50</sub> (<b>IIb</b>)/IC<sub>50</sub> (<b>IIIb</b>) of (<i>E</i>)-3-(4′-methylbenzylidene)-4-chromanone (<b>IIIb</b>) towards human Molt 4/C8 and CEM T-lymphocytes showed a >50-fold incr...

Full description

Saved in:
Bibliographic Details
Main Authors: Gábor Bognár, Fatemeh Kenari, Zoltán Pintér, Igor D. Borges, Ademir J. Camargo, Heibbe C. B. Oliveira, Flávio Olimpio Sanches-Neto, Valter H. Carvalho-Silva, Hamilton B. Napolitano, Pál Perjési
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
chalcone
homoisoflavones
benzylidenechromanones
anticancer activity
glutathione
N-acetylcysteine
Online Access:https://www.mdpi.com/1420-3049/29/23/5493
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1420-3049/29/23/5493

Similar Items