The Role of Long-Range Non-Specific Electrostatic Interactions in Inhibiting the Pre-Fusion Proteolytic Processing of the SARS-CoV-2 S Glycoprotein by Heparin

The Role of Long-Range Non-Specific Electrostatic Interactions in Inhibiting the Pre-Fusion Proteolytic Processing of the SARS-CoV-2 S Glycoprotein by Heparin

The proteolytic processing of the SARS-CoV-2 spike glycoprotein by host cell membrane-associated proteases is a key step in both the entry of the invading virus into the cell and the release of the newly generated viral particles from the infected cell. Because of the critical importance of this ste...

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Bibliographic Details
Main Authors: Yi Du, Yang Yang, Son N. Nguyen, Igor A. Kaltashov
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
coronavirus
furin
polyanion
glycosaminoglycans
non-covalent complex
multi-valence
Online Access:https://www.mdpi.com/2218-273X/15/6/778
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