Physioxia rewires mitochondrial complex composition to protect stem cell viability

Physioxia rewires mitochondrial complex composition to protect stem cell viability

Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen level different from their microenvironmental niche impacts their viability. To understand this mechanistically, dermal skin fibroblasts of 52 p...

Full description

Saved in:
Bibliographic Details
Main Authors: Janice Raabe, Ilka Wittig, Patrick Laurette, Konstantina Stathopoulou, Theresa Brand, Thomas Schulze, Birgit Klampe, Ellen Orthey, Alfredo Cabrera-Orefice, Jana Meisterknecht, Ellen Thiemann, Sandra D. Laufer, Aya Shibamiya, Marina Reinsch, Sigrid Fuchs, Jennifer Kaiser, Jiaqi Yang, Simonida Zehr, Kinga M. Wrona, Kristina Lorenz, Robert Lukowski, Arne Hansen, Ralf Gilsbach, Ralf P. Brandes, Bärbel M. Ulmer, Thomas Eschenhagen, Friederike Cuello
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Redox Biology
Subjects:
Human induced pluripotent stem cells
NDUFA4L2
HIF1α
Mitochondrial function
Senescence
Complexes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724003306
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724003306

Similar Items