Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors

Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors

Fibrosis, cardiac remodelling, and inflammation are hallmarks of heart failure. To date, there is no available pharmacological cure for heart failure, but mechanical unloading by implantation of a left ventricular assist device (LVAD) can lead to improved cardiac function in a subset of patients. Th...

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Main Authors: Rebekka Roth, Margareta Häckh, Tilman Schnick, Carolin Rommel, Christoph Koentges, Heiko Bugger, Claudia Domisch, Michael R. Bristow, Amrut V. Ambardekar, Timothy A. McKinsey, Ralf Gilsbach, Lutz Hein, Sebastian Preissl
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Epigenetics
Subjects:
Heart failure
mechanical unloading
reverse remodeling
transcriptome
epigenetics
mitochondria
Online Access:https://www.tandfonline.com/doi/10.1080/15592294.2025.2506625
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https://www.tandfonline.com/doi/10.1080/15592294.2025.2506625

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