The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review
Background: Human cytomegalovirus (HCMV) is a widespread human pathogen that triggers varying clinical symptoms depending on the host’s age and immune status. It appears that HCMV infection plays a role in the development of numerous types of cancer. This study aimed to identify the presence of HCM...
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| Format: | Article |
| Language: | English |
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Knowledge E
2024-12-01
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| Series: | Sudan Journal of Medical Sciences |
| Online Access: | https://knepublishing.com/index.php/SJMS/article/view/14571 |
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| author | Hagir Abd Rahman Mahmoud Ahmed Mohamed Suleiman Elwaleed Mohamed Elamin Sawsan Abdel Rahim Mohammed |
| author_facet | Hagir Abd Rahman Mahmoud Ahmed Mohamed Suleiman Elwaleed Mohamed Elamin Sawsan Abdel Rahim Mohammed |
| author_sort | Hagir Abd Rahman Mahmoud |
| collection | DOAJ |
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Background: Human cytomegalovirus (HCMV) is a widespread human pathogen that triggers varying clinical symptoms depending on the host’s age and immune status. It appears that HCMV infection plays a role in the development of numerous types of cancer. This study aimed to identify the presence of HCMV in different kinds of malignant salivary gland tumors in Sudanese patients.
Methods: Eighty-four formalin-fixed paraffin-embedded tissues (FFPE) from Sudanese patients previously diagnosed with salivary gland cancer (SGC) between 2014 and 2022 were selected. All cases include normal salivary gland tissue. Immunohistochemical staining for CMV was performed using monoclonal antibodies to detect the presence of the virus among the studied group.
Results: CMV was detected in only 1 out of 84 SGC cases; an adenoid cystic carcinoma. All adjacent normal salivary gland tissues were negative for the virus.
Conclusion: The absence of CMV in the studied cases suggests that the virus was not involved in developing these malignancies.
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| format | Article |
| id | doaj-art-d960aa962f74428c9c6bbe0fe0941da9 |
| institution | Kabale University |
| issn | 1858-5051 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj-art-d960aa962f74428c9c6bbe0fe0941da92025-01-21T05:40:19ZengKnowledge ESudan Journal of Medical Sciences1858-50512024-12-0119410.18502/sjms.v19i4.14571The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature ReviewHagir Abd Rahman Mahmoud0Ahmed Mohamed Suleiman1Elwaleed Mohamed Elamin2Sawsan Abdel Rahim Mohammed3Department of Oral and Maxillofacial Surgery, Faculty of Dental and Oral Medicine, Karary University, Khartoum, SudanDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Khartoum, Khartoum, SudanDepartment of Histopathology and Cytology, Molecular Biology, Faculty of Medical Lab Sciences, Al Zaeim Al Azhari University, Khartoum, SudanDepartment of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan Background: Human cytomegalovirus (HCMV) is a widespread human pathogen that triggers varying clinical symptoms depending on the host’s age and immune status. It appears that HCMV infection plays a role in the development of numerous types of cancer. This study aimed to identify the presence of HCMV in different kinds of malignant salivary gland tumors in Sudanese patients. Methods: Eighty-four formalin-fixed paraffin-embedded tissues (FFPE) from Sudanese patients previously diagnosed with salivary gland cancer (SGC) between 2014 and 2022 were selected. All cases include normal salivary gland tissue. Immunohistochemical staining for CMV was performed using monoclonal antibodies to detect the presence of the virus among the studied group. Results: CMV was detected in only 1 out of 84 SGC cases; an adenoid cystic carcinoma. All adjacent normal salivary gland tissues were negative for the virus. Conclusion: The absence of CMV in the studied cases suggests that the virus was not involved in developing these malignancies. https://knepublishing.com/index.php/SJMS/article/view/14571 |
| spellingShingle | Hagir Abd Rahman Mahmoud Ahmed Mohamed Suleiman Elwaleed Mohamed Elamin Sawsan Abdel Rahim Mohammed The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review Sudan Journal of Medical Sciences |
| title | The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review |
| title_full | The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review |
| title_fullStr | The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review |
| title_full_unstemmed | The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review |
| title_short | The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review |
| title_sort | association between human cytomegalovirus and salivary gland cancer an analytical study and literature review |
| url | https://knepublishing.com/index.php/SJMS/article/view/14571 |
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