Chitosan-encapsulated linoleic acid from Leucaena leucocephala (Lam.) de Wit. inhibits FOXL2 mutation in MNU-induced ovarian granulosa cell tumors in Wistar rats

Chitosan-encapsulated linoleic acid from Leucaena leucocephala (Lam.) de Wit. inhibits FOXL2 mutation in MNU-induced ovarian granulosa cell tumors in Wistar rats

One of the biggest challenges in drug delivery is delivering drugs to their sites of action to avoid the systemic side effects that are common with most antineoplastic drugs. This study investigates the potential of linoleic acid (LA) isolated from Leucaena leucocephala extract, encapsulated in chit...

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Bibliographic Details
Main Authors: Cletus Anes Ukwubile, Hassan Braimah Yesufu, Roland Nnaemeka Okoro, Ahamefula Anslem Ahuchaogu, Blessing Ogechukwu Umeokoli, Matthew Onyema Agu, Nnamdi David Menkiti, Patrick Akoji Ida
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Next Nanotechnology
Subjects:
Leuceana leucocephala
Chitosan nanoparticles
Linoleic acid
FOXL2 gene
Ovarian granulosa tumor
Targeted delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2949829525000609
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http://www.sciencedirect.com/science/article/pii/S2949829525000609

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