PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

Abstract Class IIa histone deacetylases (Class IIa HDACs) play critical roles in regulating essential cellular metabolism and inflammatory pathways. However, dissecting the specific roles of each class IIa HDAC isoform is hindered by the pan‐inhibitory effect of current inhibitors and a lack of tool...

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Bibliographic Details
Main Authors: Kailibinuer Kadier, Tian Niu, Baoli Ding, Boya Chen, Xuxin Qi, Danni Chen, Xirui Cheng, Yizheng Fang, Jiahao Zhou, Wenyi Zhao, Zeqi Liu, Yi Yuan, Zhan Zhou, Xiaowu Dong, Bo Yang, Qiaojun He, Ji Cao, Li Jiang, Cheng‐Liang Zhu
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
anti‐inflammatory drug development
HDAC7
proinflammatory cytokines
PROTAC
TLR4 signaling
Online Access:https://doi.org/10.1002/advs.202309459
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https://doi.org/10.1002/advs.202309459

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