Effect of continuous Ia fibre activity suppression on hyperreflexia-related spasticity and maladaptive synaptic connections in the spinal cord after injury

Abstract Spasticity is defined as the velocity-dependent hyperexcitability of the stretch reflex that develops after a central nervous system injury. Spasticity is caused by plastic neuronal changes following injury. Current treatments that block spastic muscle contractions do not promote recovery f...

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Bibliographic Details
Main Authors: Takuto Hanasaki, Keita Hanaki, Yukito Sako, Yasushi Uchiyama, Sachiko Lee-Hotta
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-09397-x
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