Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment

Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment

Background: Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)–triggered neuroadaptive changes in the maturing amygdala remain unclear. Methods: Proteomic analysis of a...

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Bibliographic Details
Main Authors: Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic, Andrew Gumbert, Jack Bergman, Preston Ge, Myriam Heiman, Marie-Eve Di Raddo, Sarah L. Withey, Bertha K. Madras, Susan R. George
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Biological Psychiatry Global Open Science
Subjects:
Adolescent neurodevelopment
Amygdala
Anxiety
Astrocytes
Cannabinoids
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174325000503
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