Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation

Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation

Abstract In 2020–2021, a “mysterious illness” struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal the presence of the marine dinof...

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Main Authors: Léana Gorse, Loïc Plessis, Stephen Wearne, Margaux Paradis, Miriam Pinilla, Rae Chua, Seong Soo Lim, Elena Pelluz, Gee-Ann TOH, Raoul Mazars, Caio Bomfim, Fabienne Hervé, Korian Lhaute, Damien Réveillon, Bastien Suire, Léa Ravon-Katossky, Thomas Benoist, Léa Fromont, David Péricat, Kenneth Neil Mertens, Amélie Derrien, Aouregan Terre-Terrillon, Nicolas Chomérat, Gwenaël Bilien, Véronique Séchet, Liliane Carpentier, Mamadou Fall, Amidou Sonko, Hadi Hakim, Nfally Sadio, Jessie Bourdeaux, Céline Cougoule, Anthony K Henras, Ana Belen Perez-Oliva, Patrice Brehmer, Francisco J Roca, Franklin L Zhong, John Common, Etienne Meunier, Philipp Hess
Format: Article
Language:English
Published: Springer Nature 2025-02-01
Series:EMBO Molecular Medicine
Subjects:
Skin Pathology
Environmental Toxins
Ribotoxic Stress Response
NLRP1 Inflammasome
Online Access:https://doi.org/10.1038/s44321-025-00197-4
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https://doi.org/10.1038/s44321-025-00197-4

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