The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics

The lactylation-macrophage interplay: implications for gastrointestinal disease therapeutics

Lactate, a key metabolic byproduct of the Warburg effect, has lately been recognized as a regulator of histone lysine lactylation, a unique post-translational modification that plays a crucial role in essential biological processes, including the regulation of gene transcription. Lactylation plays a...

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Bibliographic Details
Main Authors: Xinzhen Che, Yixin Zhang, Xiqi Chen, Guangdong Xie, Jinling Li, Chengchao Xu, Chunhua Zhang, Yong Zhu, Xinyu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
lactate
histone lactylation
macrophage plasticity
inflammatory bowel disease
postoperative ileus
gastrointestinal oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608115/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1608115/full

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