TRPC6 knockdown-mediated ERK1/2 inactivation alleviates podocyte injury in minimal change disease via upregulating Lon peptidase 1

TRPC6 knockdown-mediated ERK1/2 inactivation alleviates podocyte injury in minimal change disease via upregulating Lon peptidase 1

Minimal change disease (MCD) is a universal primary glomerular disease contributing to nephrotic syndrome. Lon peptidase 1 (LONP1) has been suggested to protect podocytes from damage during the progression of MCD. Accordingly, our research further explored the specific mechanisms of LONP1. Initially...

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Bibliographic Details
Main Authors: Jianwei Ma, Liling Ren, Qin Su, Xiuyi Lv, Min Sun, Yunbo Wei, Lili Dai, Xueyan Bian
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Transient receptor potential cation channel subfamily C member 6
extracellular signal-regulated kinase 1/2
podocyte injury
Lon peptidase 1
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2431150
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https://www.tandfonline.com/doi/10.1080/0886022X.2024.2431150

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