MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development.

MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development.

The mitochondrial Ca2+ uniporter (MCU) plays crucial role in intramitochondrial Ca2+ uptake, allowing Ca2+-dependent activation of oxidative metabolism. In recent decades, the role of MCU pore-forming proteins has been highlighted in cancer. However, the contribution of MCU-associated regulatory pro...

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Main Authors: Alison Robert, David Crottès, Jérôme Bourgeais, Naig Gueguen, Arnaud Chevrollier, Jean-François Dumas, Stéphane Servais, Isabelle Domingo, Stéphanie Chadet, Julien Sobilo, Olivier Hérault, Thierry Lecomte, Christophe Vandier, William Raoul, Maxime Guéguinou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002854
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https://doi.org/10.1371/journal.pbio.3002854

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