Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice

Gly-β-MCA is a potent anti-cholestasis agent against “human-like” hydrophobic bile acid-induced biliary injury in mice

Cholestasis is a chronic liver disease with limited therapeutic options. Hydrophobic bile acid-induced hepatobiliary injury is a major pathological driver of cholestasis progression. This study investigates the anti-cholestasis efficacy and mechanisms of action of glycine-conjugated β-muricholic aci...

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Bibliographic Details
Main Authors: Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yung Dai Clayton, Lijie Gu, Yanhong Du, Sirish K. Palle, Jianglei Chen, Tiangang Li
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Journal of Lipid Research
Subjects:
liver
bile acid
CYP7A1
nuclear receptor
drug therapy
FXR
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001548
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