Smug1 alleviates the reproductive toxicity of 5-FU through functioning in rRNA quality control

Smug1 alleviates the reproductive toxicity of 5-FU through functioning in rRNA quality control

Abstract 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent whose incorporation into nucleic acid plays an essential role in its therapeutic efficacy. 5-FU induces severe reproductive toxicity, which has been shown to be reversible. However, the underlying mechanisms have not been fully e...

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Bibliographic Details
Main Authors: Gerile Naren, Debang Li, Danni Xing, Yu Liu, Lu Wang, Na Fan, Haoran Li, Xue Bai, Xiejun Zeng, Jin Wang, Xihe Li, Siqin Bao, Buhe Nashun
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
5-FU
Smug1
Reversible reproductive toxicity
Dkc1
rRNA maturation
Mouse
Online Access:https://doi.org/10.1038/s41598-025-90330-7
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https://doi.org/10.1038/s41598-025-90330-7

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