Prominence of Mycobacterium tuberculosis biomarkers among sputum culture-negative clinic attendees, independent of Ultra status

Prominence of Mycobacterium tuberculosis biomarkers among sputum culture-negative clinic attendees, independent of Ultra status

Background: Highly-sensitive molecular tests like GeneXpert MTB/RIF Ultra improve detection of paucibacillary pulmonary tuberculosis (TB) but occasionally detect Mycobacterium tuberculosis (Mtb) DNA in sputum from culture-negative individuals, with unclear significance. We hypothesized that Ultra ma...

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Main Authors: Yingda L. Xie, Nisha Modi, Kattya Lopez, Robert Reiss, Jorge Robledo, Christie Eichberg, Nchimunya Hapeela, Elizabeth Nakabugo, Irene Anyango, Kiranjot Arora, Ronald Odero, Judi Van Heerden, Widaad Zemanay, Vaishnavi S. Kaipilyawar, Samuel Kennedy, Padmapriya Banada, Lydia Nakiyingi, Moses L. Joloba, Chad Centner, Kimberly McCarthy, Jerrold Ellner, Padmini Salgame, David Alland, Susan E. Dorman
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Infection and Public Health
Subjects:
Tuberculosis
Culture-negative
Diagnosis
Ultra
Paucibacillary
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034125001406
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