Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis
Objective: To observed the effect of a curcumin-based vaginal gel combined with electroporation for the treatment of vulvovaginal candidiasis (VVC) caused by Candida albicans. Methods: Temperature-sensitive in situ gels (ISG) were prepared using poloxamers 407 and 188 as matrices. The mass ratio of...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Traditional Chinese Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S209575482400098X |
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| author | Yizhi Zhang Xiao Chen Jing Dai Chenyun Wang Shan Ma Lina Du |
| author_facet | Yizhi Zhang Xiao Chen Jing Dai Chenyun Wang Shan Ma Lina Du |
| author_sort | Yizhi Zhang |
| collection | DOAJ |
| description | Objective: To observed the effect of a curcumin-based vaginal gel combined with electroporation for the treatment of vulvovaginal candidiasis (VVC) caused by Candida albicans. Methods: Temperature-sensitive in situ gels (ISG) were prepared using poloxamers 407 and 188 as matrices. The mass ratio of poloxamer 407 and poloxamer 188 was 7:1 with a gelation temperature of approximately 29°C and gelation time of 2.5 min. Results: Electroporation increased the transmucosal permeability of the model drug, doxorubicin and improved the antifungal effects of curcumin. In vitro antifungal experiments showed that the number of fungal colonies in curcumin ISG combined with electroporation was lower than that in pure curcumin ISG. In vivo pharmacodynamic experiments showed that, compared to the model group, curcumin ISG with electroporation inhibited the growth of C. albicans, alleviated vaginal mucosal edema, and reduced the inflammatory response. Conclusion: Curcumin ISG combined with electroporation has substantial potential for the efficient clinical treatment of VVC. |
| format | Article |
| id | doaj-art-d8f883c358a6480b96bde3acf11b1ae7 |
| institution | Kabale University |
| issn | 2095-7548 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional Chinese Medical Sciences |
| spelling | doaj-art-d8f883c358a6480b96bde3acf11b1ae72025-01-25T04:11:12ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482025-01-011217985Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasisYizhi Zhang0Xiao Chen1Jing Dai2Chenyun Wang3Shan Ma4Lina Du5School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaInformation Department, General Hospital of Western War Zone, Chengdu 610083, ChinaMinistry of Health and Security, The Fourth Clinical Center Affiliated to Chinese PLA General Hospital, Beijing 100048, ChinaSchool of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; Corresponding author.Objective: To observed the effect of a curcumin-based vaginal gel combined with electroporation for the treatment of vulvovaginal candidiasis (VVC) caused by Candida albicans. Methods: Temperature-sensitive in situ gels (ISG) were prepared using poloxamers 407 and 188 as matrices. The mass ratio of poloxamer 407 and poloxamer 188 was 7:1 with a gelation temperature of approximately 29°C and gelation time of 2.5 min. Results: Electroporation increased the transmucosal permeability of the model drug, doxorubicin and improved the antifungal effects of curcumin. In vitro antifungal experiments showed that the number of fungal colonies in curcumin ISG combined with electroporation was lower than that in pure curcumin ISG. In vivo pharmacodynamic experiments showed that, compared to the model group, curcumin ISG with electroporation inhibited the growth of C. albicans, alleviated vaginal mucosal edema, and reduced the inflammatory response. Conclusion: Curcumin ISG combined with electroporation has substantial potential for the efficient clinical treatment of VVC.http://www.sciencedirect.com/science/article/pii/S209575482400098XElectroporationVulvovaginal candidiasisTransmucosal deliveryCurcuminIn situ gels |
| spellingShingle | Yizhi Zhang Xiao Chen Jing Dai Chenyun Wang Shan Ma Lina Du Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis Journal of Traditional Chinese Medical Sciences Electroporation Vulvovaginal candidiasis Transmucosal delivery Curcumin In situ gels |
| title | Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| title_full | Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| title_fullStr | Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| title_full_unstemmed | Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| title_short | Effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| title_sort | effects of intravaginal curcumin gels combined with electroporation on vulvovaginal candidiasis |
| topic | Electroporation Vulvovaginal candidiasis Transmucosal delivery Curcumin In situ gels |
| url | http://www.sciencedirect.com/science/article/pii/S209575482400098X |
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