High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform

IntroductionCarbapenemase-producing bacteria undermine the efficacy of carbapenems, a class of last-resort antibiotics used primarily to treat infections caused by multidrug-resistant Gram-negative pathogens. Carbapenemases are among the most alarming antimicrobial resistance mechanisms because they...

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Bibliographic Details
Main Authors: Sascha D. Braun, Martin Reinicke, Celia Diezel, Elke Müller, Katrin Frankenfeld, Thomas Schumacher, Hugo Arends, Stefan Monecke, Ralf Ehricht
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1650094/full
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