Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial

Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial

Introduction Traumatic brain injury (TBI) often causes permanent neurological dysfunction. Although no medication has been validated yet to prevent secondary injury of brain tissue, recent animal studies have reported that perampanel, a glutamine receptor antagonist, could improve the neurological f...

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Main Authors: Ryota Tamura, Yuki Kuranari, Yukina Morimoto, Masahiro Toda, Tokunori Kanazawa, Makoto Inaba, Ryo Yamamoto, Koichiro Homma, Takahiro Shoji, Junichi Sasaki, Masayuki Shimizu, Masato Nakaya, Satoshi Terao, Ryota Sasao, Makoto Katayama, Koichi Ueno, Yumiko Oishi, Akiyoshi Nakamura, Yo Kikuo, Ryosuke Murakami, Sota Wakahara, Konosuke Ishikawa, Kenzo Kosugi, Tatsuro Ozaki
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e105190.full
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https://bmjopen.bmj.com/content/15/8/e105190.full

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