C118P Suppresses Gastric Cancer Growth via Promoting Autophagy–Lysosomal Degradation of RAB1A
<b>Background/Objectives</b>: Gastric cancer (GC) is the leading cause of cancer-related deaths worldwide. C118P, a microtubule inhibitor with anti-angiogenic and vascular-disrupting activities, was proven to be cytotoxic to various cancer cell lines. This study aimed to explore the anti...
Saved in:
Main Authors: | Shihui Wei, Jing Zhang, Hai Wu, Zhengguang Liao, Zhengrui Liu, Yuhang Hou, Danyu Du, Jingwei Jiang, Li Sun, Shengtao Yuan, Mei Yang |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-12-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/16/12/1620 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning
by: Aleksandra Janusz-Kaminska, et al.
Published: (2024-12-01) -
ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer
by: Bo Shi, et al.
Published: (2025-01-01) -
Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease
by: Hongling Zhu, et al.
Published: (2025-01-01) -
The Antipsychotic Drug Aripiprazole Suppresses Colorectal Cancer by Targeting LAMP2a to Induce RNH1/miR‐99a/mTOR‐Mediated Autophagy and Apoptosis
by: Hui‐Fang Hu, et al.
Published: (2024-12-01) -
Targeting mTOR Kinase with Natural Compounds: Potent ATP-Competitive Inhibition Through Enhanced Binding Mechanisms
by: Sulaiman K. Marafie, et al.
Published: (2024-12-01)