Indomethacin Abolishes the Potentiation Effect of Testosterone on the Relaxation Induced by Salbutamol and Theophylline by Directly Blocking the K<sup>+</sup> Channels in Airway Smooth Muscle

Indomethacin Abolishes the Potentiation Effect of Testosterone on the Relaxation Induced by Salbutamol and Theophylline by Directly Blocking the K<sup>+</sup> Channels in Airway Smooth Muscle

Indomethacin, ibuprofen, and acetylsalicylic acid (ASA) are non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit prostaglandin (PG) synthesis. Previous studies in airway smooth muscle demonstrated that chronic exposure to testosterone (TES, 40 nM) enhances the relaxation induced by salbutamol...

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Bibliographic Details
Main Authors: Jorge Reyes-García, Abril Carbajal-García, Verónica Díaz-Hernández, María F. Casas-Hernández, Luis M. Montaño
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
airway smooth muscle
testosterone
salbutamol
theophylline
indomethacin
ibuprofen
Online Access:https://www.mdpi.com/1420-3049/30/11/2259
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