Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury

Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury

Abstract Acute kidney injury (AKI) involves the activation of intrarenal hemostatic and inflammatory pathways. Platelets rapidly migrate to affected sites of AKI and release extracellular vesicles (EVs) laden with bioactive mediators that regulate inflammation and hemostasis. While small interfering...

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Main Authors: Jiafan Wang, Hai Huang, Meng Jia, Si Chen, Fengjuan Wang, Guiyang He, Chong Wu, Kaibin Lou, Xuexue Zheng, Heng Zhang, Chao Qin, Yanggang Yuan, Ke Zen, Hongwei Liang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Acute kidney injury
Platelets
Self-assembling nanoparticles
Transformation-related protein 53
Online Access:https://doi.org/10.1186/s12951-025-03338-6
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https://doi.org/10.1186/s12951-025-03338-6

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