SHIP identifies genomic safe harbors in eukaryotic organisms using genomic general feature annotation

SHIP identifies genomic safe harbors in eukaryotic organisms using genomic general feature annotation

Abstract Integrating foreign genes into loci, allowing their transcription without affecting endogenous gene expression, is the desirable strategy in genomic engineering. However, these loci, known as genomic safe harbors (GSHs), have been mainly identified by empirical methods. Furthermore, the mos...

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Main Authors: Matheus de Castro Leitão, Letícia Sousa Cabral, Luiza Cesca Piva, Pedro Felipe de Sousa Queiroz, Taísa Godoy Gomes, Rosângela Vieira de Andrade, Ana Laura Alfonso Perez, Karen Letycia Rodrigues de Paiva, Sônia Nair Báo, Viviane Castelo Branco Reis, Lídia Maria Pepe Moraes, Roberto Coiti Togawa, Leila Maria Gomes Barros, Fernando Araripe Gonçalves Torres, Georgios Joannis Pappas Júnior, Cíntia Marques Coelho
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-91249-9
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https://doi.org/10.1038/s41598-025-91249-9

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