ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity

ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity

Abstract Background Atherosclerosis (AS) is the most common cardiovascular disease (CVD), despite an overall declining incidence, AS remains a leading cause of death worldwide. The ZeXieYin formula (ZXYF), one of the thirteen formulas recorded in HuangDiNeiJin, a classical book of Traditional Chines...

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Main Authors: Shihan Zhou, Shangbo Hua, Xinyi Chen, Meiling Ni, Jing Liu, Yanqing Wang, Wanning Wu, Anni Ding, Zizhen Qin, Xinyu Yang, Xiaowei Chen, Boran Zhu, Haoxin Wu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Chinese Medicine
Subjects:
Atherosclerosis
ZeXieYin formula
Secondary bile acids
Gut microbiota
Metabolomics analysis
Online Access:https://doi.org/10.1186/s13020-025-01116-y
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https://doi.org/10.1186/s13020-025-01116-y

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