ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence

ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence

Abstract Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four‐generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkag...

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Bibliographic Details
Main Authors: Yi Wang, Qiang Wu, Yongqing You, Wenbo Jiang, Peiliang Fu, Kerong Dai, Ye Sun
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
ABCA6
cellular senescence
cholesterol efflux
chondrogenesis
osteoarthritis
patellar dysplasia
Online Access:https://doi.org/10.1002/advs.202410414
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https://doi.org/10.1002/advs.202410414

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