Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

Abstract Targeted protein degradation has been widely adopted as a new approach to eliminate both established and previously recalcitrant therapeutic targets. Here, it is reported that the development of small molecule degraders of the envelope (E) protein of dengue virus. Two classes of bivalent E‐...

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Bibliographic Details
Main Authors: Zhengnian Li, Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang, Inchul You, Hong Yue, Katherine A. Donovan, Guangyan Du, Jianwei Che, Jason Tse, Isaac Che, Wenchao Lu, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
antivirals
dengue
envelope protein
infection
protein degradation
Online Access:https://doi.org/10.1002/advs.202405829
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https://doi.org/10.1002/advs.202405829

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