P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate

P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate

Abstract Multidrug resistance proteins contribute to chemotherapy resistance in various cancers. Among them, the P-glycoprotein (P-gp) has been the most investigated. These works aim to evaluate the efficacy of the new fluorescent tracer LightSpot-FL-1 for quantifying P-gp in CCRF-CEM and KG-1a acut...

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Main Authors: Maxime Dubois, Antoine Goisnard, Céline Bourgne, Elodie Gay, Marie Depresle, Manon Roux, Allison Voisin, Marc Berger, Frédérique Penault-Llorca, Emmanuelle Mounetou, Pierre Daumar, Mahchid Bamdad
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Multi-drug resistance
P-gp
LightSpot-FL-1 fluorescent probe
Daunorubicin
Acute leukemia
Online Access:https://doi.org/10.1038/s41598-025-03370-4
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https://doi.org/10.1038/s41598-025-03370-4

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