Human dental pulp stem cells attenuate airway inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting the pyroptosis pathway

Human dental pulp stem cells attenuate airway inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting the pyroptosis pathway

Abstract Background Fine particulate matter (PM2.5) exposure significantly exacerbates respiratory morbidity, particularly in asthmatic individuals, highlighting an urgent need for effective therapeutic interventions. In this study, we evaluated the therapeutic potential and underlying mechanisms of...

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Main Authors: Jianling Liu, Yuehua Chen, Zhongpeng Li, Zhangwen Li, Fengjuan Lyu, Fang Wang, Aili Wang, Zhangquan Liu, Xiaoyang Liao, Jian Wu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human dental pulp stem cells
Airway inflammation
PM2.5-induced asthma exacerbation
Pyroptosis
Cell therapy
Online Access:https://doi.org/10.1186/s13287-025-04368-5
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https://doi.org/10.1186/s13287-025-04368-5

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