Optogenetic activation of mechanical nociceptions to enhance implant osseointegration

Optogenetic activation of mechanical nociceptions to enhance implant osseointegration

Abstract Orthopedic implants with high elastic modulus often suffer from poor osseointegration due to stress shielding, a phenomenon that suppresses the expression of intracellular mechanotransduction molecules (IMM) such as focal adhesion kinase (FAK). We find that reduced FAK expression under stre...

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Main Authors: Qijin Wang, Yang Chen, Haiqi Ding, Yuanqing Cai, Xuhui Yuan, Jianhua Lv, Jiagu Huang, Jiexin Huang, Chaofan Zhang, Zihao Hong, Hongyan Li, Ying Huang, Jiamin Lin, Lin Yuan, Lan Lin, Shaolin Yu, Canhong Zhang, Jianhua Lin, Wenbo Li, Cheng Chang, Bin Yang, Wenming Zhang, Xinyu Fang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58336-x
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https://doi.org/10.1038/s41467-025-58336-x

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