Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes

Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes

Abstract Background Several new treatments have recently been shown to have heart and kidney protective benefits in people with diabetes. Because these treatments were developed in parallel, it is unclear how the different molecular pathways affected by the therapies may overlap. Here, we examined t...

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Main Authors: Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Diabetology & Metabolic Syndrome
Subjects:
CCN2
CTGF
Diabetic nephropathy
Finerenone
Gastric inhibitory polypeptide
GLP-1
Online Access:https://doi.org/10.1186/s13098-024-01525-3
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https://doi.org/10.1186/s13098-024-01525-3

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