Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma

Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma

Abstract Background The sophisticated tumour microenvironment is responsible for the malignant progression and poor prognosis of hepatocellular carcinoma (HCC). Discovering new therapeutic targets is desired for the preferable treatment of HCC patients. Methods To characterize the HCC microenvironme...

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Bibliographic Details
Main Authors: Wenhao Hou, Jiaqi Jiang, Liyuan Zhu, Hongwei Xu, Lihui Zhu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
B cell-related immunosuppressive landscape
Hepatocellular carcinoma
Serum amyloid A2
Single-cell RNA sequencing
Suppressor
Tumour microenvironment
Online Access:https://doi.org/10.1186/s12967-025-06869-6
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https://doi.org/10.1186/s12967-025-06869-6

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