Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro

Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro

Abstract Human airways contain specialized rare epithelial cells including CFTR-rich ionocytes that regulate airway surface physiology and chemosensory tuft cells that produce asthma-associated inflammatory mediators. Here, using a lung cell atlas of 311,748 single cell RNA-Seq profiles, we identify...

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Main Authors: Viral S. Shah, Avinash Waghray, Brian Lin, Atharva Bhagwat, Isha Monga, Michal Slyper, Bruno Giotti, Sunghyun Kim, Dawei Sun, Ke Xu, Eric Park, Mohamad Bairakdar, Jiajie Xu, Julia Waldman, Danielle Dionne, Lan T. Nguyen, Wendy Lou, Peiwen Cai, Christoph Muus, Jiawei Sun, Manalee V. Surve, Lujia Cha Cha Yang, Orit Rozenblatt-Rosen, Toni M. Delorey, Srinivas Vinod Saladi, Aviv Regev, Jayaraj Rajagopal, Alexander M. Tsankov
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60441-w
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https://doi.org/10.1038/s41467-025-60441-w

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