Rapamycin-induced small extracellular vesicles under GelMA scaffolds facilitate diabetic wound repair through accelerating angiogenesis and alleviating macrophage-mediated inflammation via PI3K/Akt signaling pathway

Rapamycin-induced small extracellular vesicles under GelMA scaffolds facilitate diabetic wound repair through accelerating angiogenesis and alleviating macrophage-mediated inflammation via PI3K/Akt signaling pathway

Recently, small extracellular vesicles (sEVs) isolated from mesenchymal stem cells (MSCs) show superior therapeutic potential in diabetic wound repair. Pretreated MSCs with biological or chemical agents could boost the activities of MSC-derived sEVs. This study aims to investigate whether sEVs deriv...

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Bibliographic Details
Main Authors: Yalu Zhang, Zekun Wang, Liang Wu, Liang Zhu, Ming Lu, Ziyang Zhang, Yuanhao Lv, Xu Zhu, Hanhui Yao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Esenchymal stem cells
Small extracellular vesicles
Rapamycin
Diabetic wound
PI3K/Akt signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004065
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