High-expression of BCL10 inhibits cell-mediated immunity within the tumor immune microenvironment

High-expression of BCL10 inhibits cell-mediated immunity within the tumor immune microenvironment

BackgroundB-cell lymphoma 10 (BCL10) is a key signaling molecule that plays a pivotal role in activating the NF-κB signaling pathway. However, it is unclear whether prolonged activation of BCL10 within tumors lead to T cell exhaustion and suppress immune responses against cancer.MethodsIn this study...

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Bibliographic Details
Main Authors: Jinyi Gu, Changshun Chen, Yuanjing Chen, Wei Lv, Fei Li, Puyuan Zhu, Pu He, Yunjie Du, Huiling Liu, Bingdong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
B-cell lymphoma 10 (BCL10)
tumor immune microenvironment (TIME)
CD8+T cells
cervical squamous cell carcinoma(CESC)
NF-κB signaling pathway
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616321/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1616321/full

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